Yep. I actually do both. Wireguard on Oracle Cloud for my Plex.

Cloudflare to serve up stuff like Overseerr & my WordPress blog.

I actually do use raw Wireguard on an Oracle VCN instance so I can share my Plex on T-Mobile Home Internet.

(Plex is against Cloudflare’s ToS, which is why I don’t use them for Plex)

Tailscale is good for people who are techy enough to use it. But it’s not much help for my grandma if she wants to watch a Plex movie on her Roku.

Cloudflare is nice if your ISP uses CGNAT or blocks incoming port traffic (e.g. Starlink or T-Mobile 5G Home Internet).