Katrina

You can do it. I set mine up ages ago. https://docs.pi-hole.net/guides/dns/cloudflared/

I’m not sure you could even run pihole on 512MB RAM.

And the biggest disadvantage of IPv6 is that each of your internal devices has its own address and can be directly accessible from outside. So you need to completely rethink how you do security.

DNS obviously, I use the Pi-hole compatible filtering in OpnSense Then Nextcloud, Email, Navidrome, Jupyter Hub, Code-Server